As you may already know, Intune is offering a Hotpatch for Patch Tuesday to allow installing Windows Updates without having to restart devices (see Intune – Hotpatch is becoming available for client devices).
Well, we (at the company I’m working for) found an issue with the May 2025 updates.
After getting the May 2025 updates installed in Hotpatch mode on ARM devices, applications are crashing very quickly after launch – the applications we have identified are Acrobat Reader and SQL Management Studio but obviously more may be impacted; Office apps do not seem to be impacted.
The issue seems to impact only ARM Devices with Hotpatch capability (you can identify the update Hotpatch capable with the (Hotpatch capable) text shown under the update).
At this stage, it does not seem Microsoft is aware (no know issue related to the corresponding KB) and on other forums/tech sites nothing has been found.
So, you may be impacted if:
- You have configured Intune to enable Hotpatch
- You are running ARM devices
If both of the above are true, you will need to uninstall a specific KB update and look to block it – unfortunately there is no option to block a specific KB update in Intune 
The specific KB identified seems to be KB 5058497 – Cumulative Update for Windows 11 24H2 for arm64-based Systems)
After you uninstall this specific KB (5058497) using the command prompt (running as administrator) below and restart, your crashing applications should be back to working mode
wusa /uninstall /kb:5058497
It seems this only impacting ARM devices with Hotpatch enabled; ARM devices with ‘standard’ (aka reboot after update) do not seem to be impacted.